![]() We also show that AIDS has likely afflicted chimpanzees long before the emergence of HIV. We discuss how host restriction factors have shaped the emergence of new SIV zoonoses by imposing adaptive hurdles to cross-species transmission and/or secondary spread. However, one transmission event, involving SIVcpz from chimpanzees in southeastern Cameroon, gave rise to HIV-1 group M-the principal cause of the AIDS pandemic. Most of these transfers resulted in viruses that spread in humans to only a limited extent. Both HIVs are the result of multiple cross-species transmissions of simian immunodeficiency viruses (SIVs) naturally infecting African primates. ![]() Here, we describe the origins and evolution of these viruses, and the circumstances that led to the AIDS pandemic. Acquired immunodeficiency syndrome (AIDS) of humans is caused by two lentiviruses, human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2).
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